A cohort study of in utero polychlorinated biphenyl (PCB) exposures in relation to secondary sex ratio
نویسندگان
چکیده
منابع مشابه
A cohort study of in utero polychlorinated biphenyl (PCB) exposures in relation to secondary sex ratio
BACKGROUND Polychlorinated biphenyls (PCBs) are ubiquitous industrial chemicals that persist in the environment and in human fatty tissue. PCBs are related to a class of compounds known as dioxins, specifically 2,3,7,8-TCDD (tetrachloro-dibenzodioxin), which has been implicated as a cause of altered sex ratio, especially in relation to paternal exposures. METHODS In the 1960's, serum specimen...
متن کاملA cohort study of the association between secondary sex ratio and parental exposure to polybrominated biphenyl (PBB) and polychlorinated biphenyl (PCB)
BACKGROUND Polybrominated biphenyl (PBB), a brominated flame retardant, was accidently mixed into animal feed in Michigan (1973-1974) resulting in human exposure through consumption of contaminated meat, milk and eggs. Beginning in 1976 individuals who consumed contaminated products were enrolled in the Michigan Long-Term PBB Study. This cohort presents a unique opportunity to study the associa...
متن کاملSecondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury
This study was undertaken to assess the potential impact of maternal exposures to polychlorinated biphenyl (PCB), dichlorodiphenyl dichloroethylene (DDE) and methylmercury on the secondary sex ratios (the ratio of male to female live births) over a span of 23 years. The study includes prospective data from three Faroese birth cohorts, with a total of 2,152 healthy mother-child dyads recruited b...
متن کاملMaternal exposure to polychlorinated biphenyls and the secondary sex ratio: an occupational cohort study
BACKGROUND Though commercial production of polychlorinated biphenyls was banned in the United States in 1977, exposure continues due to their environmental persistence. Several studies have examined the association between environmental polychlorinated biphenyl exposure and modulations of the secondary sex ratio, with conflicting results. OBJECTIVE Our objective was to evaluate the associatio...
متن کاملSecondary Sex Ratio among Women Exposed to Diethylstilbestrol in Utero
BACKGROUND Diethylstilbestrol (DES), a synthetic estrogen widely prescribed to pregnant women during the mid-1900s, is a potent endocrine disruptor. Previous studies have suggested an association between endocrine-disrupting compounds and secondary sex ratio. METHODS Data were provided by women participating in the National Cancer Institute (NCI) DES Combined Cohort Study. We used generalized...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental Health
سال: 2008
ISSN: 1476-069X
DOI: 10.1186/1476-069x-7-37